Projects
Projects of the second funding period
- J. Köhrle : Z-Project: Analytical procedures for the determination of the thyroid hormone status in biological samples collected in the framework of the priority programme SPP 1629
- G. Krause : Molecular determinants of different thyroid hormone uptake/ efflux mechanisms for L-type amino acid transporter subtypes
- H. Biebermann : Identification of 3-iodothyronamine-induced signaling network in neuromodulation
- G. Homuth, J. Köhrle : Effects of thyronamines (TAM) and thyroacetic acid (TAC) metabolites on energy metabolism, mitochondrial function, Ca2+-signalling, plasma membrane action
- C. Höfig : NAc-3-T1AM: a novel hormone connecting thyroid and cardiovascular function
- H. Heuer : The tissue-specific role of the murine thyroid hormone transporters Mct8 and Mct10
- H. Heuer, J. Mittag : Role of the murine thyroid hormone transporters Mct8 and Oatp1c1 in skeletal muscle, cardiovascular and metabolic system
- K. Brix : Auto-regulation of the thyroid gland by classical and non-classical pathways
- U. Schweizer, C. Steegborn : Biochemical and structural characterization of mammalian deiodinases as key regulators of thyroid hormone metabolism
- L. Moeller : Non-classical thyroid hormone action mediated by thyroid hormone receptor alpha and beta
- J. Mittag : Non Classical Concepts of Thyroid Hormone Action in the Regulation of Body Temperature
- H. Müller-Fielitz : Role of tanycytes in the non-classical feedback regulation of the hypothylmic-pituitary-thyroid axis
- G. Brabant, T. Münte, A. Sartorius : The influence of thyroid hormones, receptors, and transporters on brain structure and function
- D. Führer : Molecular mechanisms of age-dependent thyroid hormone action on target tissues
- D. Zwanziger : Role of Tight Junctions in Gallstone Formation under Hypothyroidism
- K. Krause : Definition of central and cellular effects of thyroid hormones on white adipose tissue browning
- L. Hofbauer, M. Rauner : Role of Wnt signaling in classical and non-classical thyroid hormone actions (T0-T4) on bone
- P. Nelson, C. Spitzweg : Plasma membrane-mediated non-genomic effects of T4, T3 and thyroid hormone metabolite tetrac on different aspects of mesenchymal stem cell biology and their signaling pathways
- G. Brabant, J. Mittag : Unraveling the molecular basis for successful thyroid hormone replacement therapy
- G. Brabant, N. Friedrich, D. Führer, U. Völker : Integrated-OMICs analyses to identify pathways associated with thyroid hormones and their molecular regulators: Screening for new markers to assess thyroid hormone action
Projects of the first funding period
WP1: What defines the healthy thyroid status of an individual?
- U. Schweizer : Structure and function of the thyroid hormone transporter MCT8
- H. Heuer : Tissue-specific role of the murine thyroid hormone transporters Mct8 and Mct10
- E. Wirth, U. Schweizer : Cell type-specific inactivation of Mct8 in brain cells: Gene expression, metabolism, morphology
- A. Kinne, G. Krause : Role of the L-type amino acid transporter Lat2 in transport of thyroid hormones
- C. Stäubert, T. Schöneberg : Trace amine-associated receptors (TAAR) as targets for thyronamines
- H. Biebermann : 3-iodothyronamine induced signaling of Trace Amine-Associated Receptor subtypes and their role in neuromodulation
- L. Schomburg : Biomarkers of Thyronamine Action (BioTAct)
- L. Moeller : Nonclassical thyroid hormone signaling mediated by thyroid hormone receptor beta
WP2: When and how does an organ respond to TH?
- T. Münte, G. Brabant : Consequences of short-term hypo- and hyperthyroidism on brain structure and function in humans
- D. Führer, U. Schweizer : Oral thyroxine resistance revisited – how thyroxine transpasses the gut-blood barrier
- K. Brix : Auto-regulation of the thyroid gland by classical and non-classical pathways
- D. Führer : Molecular mechanisms of age- and gender-dependent thyroid hormone action on target tissues
- J. Köhrle, S. Mergler : Effects of thyronamines (TAM) and thyroacetic acid (TAC) metabolites on energy metabolism – mitochondrial function, Ca2+-signalling, plasma membrane action
- A. Tönjes, S. Hesse, K. Krause : Interaction of thyroid hormones and brown adipose tissue
- C. Spitzweg, P. Nelson : Plasma membrane-mediated non-genomic effects of T4, T3 and thyroid hormone metabolite Tetrac on the tumor microenvironment
WP3: How can TH dependent diseases be prevented?
- H. Völzke, M. Dörr : Association of serum reverse triiodothyronine, diiodothyronine and thyronamine levels with cardiovascular risk factors and disorders
- U. Völker, N. Friedrich, G. Homuth : Identification of pathways associated with thyroid hormones and their molecular regulators by integrated -OMICs analyses of cross-sectional and longitudinal studies in the general population and selected patients